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Department of Chemistry & Biochemistry

Dr. Raghu
Assistant Professor

Degree Subject University, place ,year
B.Sc. (Phy, Chem, Maths) University of Mysore, 2002
M.Sc. Chemistry University of Mysore, 2004
Ph.D. Chemistry University of Mysore, 2016



Qualification:M.Sc., Ph.D.
Research Experience :10 years
Teaching Experience:5 years

  • • Topics of Current Research Interest:

      Synthesis of Heterocyclic compounds, characterization and their biological evaluation.

  • • Research experience:

      Company: Biocon Research Center(Asia’s biggest Bio-Pharmaceutical Company) Electronic city, Bangalore-560100. INDIA.

      Offering 10+ Years of Cross-functional exposure to Research in the areas of Organic Chemistry & Medicinal Chemistry.

      Department: Research & Development (R&D)-Synthetic Chemistry Division. Post: Associate Scientific Manager.

  • • Research Publications:

      1. Raghu Ningegowda, Design and Synthesis of novel substituted 3-(2-(1,3,4-thiadiazol-2-ylamino)acetyl)-2H-selenopyrano[2,3-b]quinolin-2-ones, Journal of chemical data Collection, 35 (2021), 100748 (https://doi.org/10.1016/j.cdc.2021.100748)

      2. Raghu Ningegowda* “Synthesis and Characterization of Indolizine and 5,6-benzo-fused Indolizine derivatives with their pharmacological applications” Journal of Chemical Data Collection, (2020) 100524 (https://doi.org/10.1016/ j.cdc.2020.100524).

      3.Raghu Ningegowda* “Selenium containing heterocycles: Synthetic investigations of some new series 3-(5-mercapto-1,3,4-oxadiazol-2-yl)-2H-selenopyrano[2,3-b] quinolin-2-ones” Journal of Chemical Data Collection, 29 (2020) 100510 (https://doi.org/10.1016/ j.cdc.2020.100510).

      4.Raghu Ningegowda*“Design, synthesis and characterization of novel 2-(2, 3-dichlorophenyl)-5-aryl-1, 3, 4-oxadiazole derivatives for their anti-tubercular activity against Mycobacterium tuberculosis.” Journal of Chemical Data Collection, 28 (2020) 100431. (https://doi.org/10.1016/ j.cdc.2020.100431).

      5. Raghu Ningegowda* “Synthesis, antibacterial, and antioxidant studies of 7-amino-3-)4-fluorobenzoyl)indolizine-1-carboxylate derivatives”, Journal of Applied Pharmaceutical Science, Vol. 10, Issue (02), Page No. 077-085,February 2020, DOI: 10.7324/ JAPS.2018.8801 ISSN 2231-3354.

      6. Raghu Ningegowda* “Synthesis, Anti-bacterial and Antioxidant Properties of Ethyl 7-Amino-3-Benzoyl-2-Methylindolizine-1-Carboxylate Derivatives” Manuscript has been successfully submitted to the proceedings of International Conference on Advances in Materials Research (ICAMR - 2019). MS ID: AIPCP20-AR-ICAMR2019-00097

      7. Raghu Ningegowda* “Microwave induced synthesis, and pharmacological properties of novel 1-benzoyl-4-bromopyrrolo [1, 2-a] quinoline-3- carboxylate analogues,” Journal of Chemical Data Collection, Volume 25(2020), Page 100316, December-2019, (https://doi.org/10.1016/ j.cdc.2019.100316).

      8. Raghu Ningegowda*.“A Novel and Expeditious Synthesis of oxazolidinone drugs Linezolid and Eperezolid”. European Journal of Chemistry, 9 (4) 2018, 353-359.

      9. Raghu Ningegowda* “A Mild and efficient method for the de-protection of trimethyl silyl alkynes using Sodium Ascorbate and copper sulphate” European Journal of Chemistry, 9 (4) 2018, 317-321.

      10. Raghu Ningegowda*, Nanjunda Swamy Shivananju, Peramiyan Rajendran, Babu Shubha Priya “A novel 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivative inhibits tumor cell invasion and potentiates the apoptotic effect of TNFα by abrogating NF-κB activation cascade”. Apoptosis, 22(1):145-157, 2017.

      11. Raghu Ningegowda,*Savitha Bhaskaran, Ayyiliath. M.Sajith, Padusha, NanjundaSwamy S, B. S. Priya“Mo(CO)6 as solid CO source in the synthesis of aryl / heteroarylweinreb amides under microwave enhanced condition. ”Aus. J. of Chemistry.2016, 70(1) 44-51.

      12. Shubhavathi T, Mallesha Ningegowda, Nanjundaswamy S, Raghu Ningegowda*,Ranjith S. B.S Priya. “Eaton’s reagent catalyzed Alacritous synthesis of 3-Benzazepinones.” European Journal of Chemistry, 2016, 7(4)-391-396.

      13. Raghu Ningegowda*, NanjundaSwamy. S, Raghu Ram Achar, Basappa, S.L. Gaonkar, S. Ranjith, George W. Yip, B.S. Priya “A new class of isobenzofuran-5-carboxamide derivatives: synthesis, studies on induction of apoptosis andinhibition cancer cell proliferation.” Asian Journal of Biochemical and Pharmaceutical Research.2015, 2, (5),186-197.

      14. Raghu Ningegowda*. “Synthesis, invitro and invivo anti-hyperglycemic activity of 1, 2, 4-triazolebenzylidene and 1, 3, 4-thiadiazole derivatives.” International Journal of PharmTech Research. 2014, 6(4), 1245-1255.

      15. Chandrasekhar Aswathanarayanappa, Raghu Ningegowda*, M. C. Shiva Kumar, S. K. Peethambar, and Sandeep Telkar “5-phenyl-1-benzofuran-2-yl derivatives: synthesis, antimicrobial, and antioxidant activity.” Med Chem Res. 2013, 22, 78–87.

      16. Raghu Ningegowda*.“Synthesis and Evaluation of AntioxidantPropertiesof Novel 1, 2, 4-Triazole Based Schiff Base Heterocycles.” Arch. Pharm. Chem. Life Sci.2013, 346, 7, 1–9.

      17. Raghu Ningegowda*, “Phenethylamide derivatives: Synthesis and evaluation of antimicrobial and Antioxidant activity”. Der Pharma Chemica, 2012, 4(1):399-406.

      18. Chandrasekhar Aswathanarayanappa, Eswarappa Bheemappa, Raghu Ningegowda*, Peethambar “Synthesis, Antimicrobial and Antioxidant Activity Studies of Phenoxyacetamide derivatives.” Inventi Rapid: Med Chem.2012, 2, 90-93.

      19. Raghu Ningegowda,* Amit Grover, Basappa, S.Ranjith, Kanchugarakoppal S.Rangappa, B.S.Priya.S. Nanjundaswamy. “Synthesis, characterization and in vitro anti-tumor activities of novel 9-ethyl-9H-purine derivatives.” Invest. New Drugs.2010, 28, 754-765.

      20. Raghu Ningegowda,* C.V. Kavitha, B.S.Priya, S.L. Gaonkar, M.V. Tejesvi, K.S. Rangappa and S. Nanjundaswamy. “Microwave-Assisted Solvent-Free Synthesis of N-alkyl Benzotriazole Derivatives: Antimicrobial Studies.” Letters in Drug Design & Discovery. 2009, 6(7), 502-507

  • • Patents filed (National/ International) / published

      1. Raghu Ningegowda, Sandeep Chandrashekharappa, Govindappa Banuprakash; “N-(4-fluorophenyl)-5-phenyl-[1,2,4] triazolo [1,5-a] pyridine-2-carboxamide derivatives and their synthesis thereof.” Indian Pat. Appl. (2020), IN 202041006661 A 20200313 or J. Ind. Pat. Office, Issue 11/2020, 13/03/2020, IN 202041006661 A. ( Ref: www.ipindia.gov.in/journal-patents.htm) page No-56 Granted on 20-06-2022, Patent Number: 399540

      2. Raghu Ningegowda, Sandeep Chandrashekharappa, Govindappa Banuprakash; “N-(4-fluorophenyl)-5-phenyl-[1,2,4] triazolo [1,5-a] pyridine-2-carboxamide derivatives and their synthesis thereof.” International PCT Application No; PCT/IB2020/057045 (File date: 26-07-2020) (PCTIB2020057045). International Publication Number: WO 2021/161084 A1, International Publication Date: 19-Aug-2021

      3. Raghu Ningegowda, Ranjith Siddaraju, Sandeep Chandrashekharappa, Govindappa Banuprakash “Design, Synthesis and Characterization of a novel (S)-3-(5-fluoropyridin-2-yl)-5-(piperidin-3-yl)-1,2,4-oxadiazole derivatives and their Secretory Phospholipase A2 (sPLA2) inhibitor activity Thereof.” Indian Patent Application No: 202041042387. Filing date: 29-Sep-2020 or J. Ind. Pat. Office, Issue 17/2021, 23/04/2021, IN 202041042387 A. ( Ref: www.ipindia.gov.in/journal-patents.htm) page No-73

      4. Raghu Ningegowda, Ranjith Siddaraju, Sandeep Chandrashekharappa, Govindappa Banuprakash “Design, Synthesis and Characterization of a novel (S)-3-(5-fluoropyridin-2-yl)-5-(piperidin-3-yl)-1,2,4-oxadiazole derivatives and their Secretory Phospholipase A2 (sPLA2) inhibitor activity Thereof.” International PCT Application No; PCT/IB2021/052556 (File Date: 27-03-2021) (PCTIB2021052556). International Publication Number: WO 2022/069953 A1, International Publication Date: 07-April-2022

  • • Papers communicated:

      1. Raghu Ningegowda* “Design, synthesis and characterization of novel 2-(2, 3-dichlorophenyl)-5-aryl-1,3,4-oxadiazole derivatives for their anti-tubercular activity against Mycobacterium tuberculosis.” Submitted (Under Review – May -2020)

  • • Patent:

      Dr. Raghu Ningegowda*
      Title of the Invention: Multistep synthesis and pharmacological properties of novel N-(4-fluorophenyl)-5-phenyl-[1,2,4] triazolo [1,5-a] pyridine-2-carboxamide derivatives Thereof.
      Indian Pat. Appl. (2020), IN 202041006661 A20200313.

      Dr. Raghu Ningegowda from Dept. of Chemistry awarded a patent from Govt. of India for his invention entitled “N-(4-fluorophenyl)-5-phenyl-[1,2,4] triazolo [1,5-a] pyridine-2-carboxamide derivatives and their synthesis thereof.”
      Patent No: 399540
      Date of Grant: 20-06-2022

  • • Papers presented in National / International Conference.

      1. Synthesis, Characterization and In Vitro Anti-tumor Activities of 9-Ethyl-9H-purine Derivatives. “Recent Trends in chemical Research”. (NCRTCR-2014) 3rd& 4thof January, Sri Jayachamarajendra College of Engineering, Mysore,Karnataka.

      2. “Mo (CO) 6 as solid CO source in the synthesis of Aryl/Heteroaryl carboxylic acid under microwave enhanced condition”. UGC-CPE sponsored one day national conference on “Emerging Trends In Material Science” (ETMS-2018) on 5thOctober-2018, S. Nijalingappa college, KLE Society. Bangalore- 560010.

      3. “Chemical Synthesis, Characterization of substituted 1, 2, 4-triazole-3-thiol derivatives and their role as dual Akt / mTOR inhibitors which inhibits growth and induces apoptosis through the suppression of Akt / mTOR pathways of hepatocellular carcinoma”. UGC-CPE Sponsored 3-day international conference on “Advanced Functional Materials for Energy, Environment and Health care” (AFMEEHC) on 18-20th March -2019 Center for Material Science & Technology(CMST), Vijnana Bhavan, Manasagangotri, Mysore, INDIA-570006.

      4.“A Mild and efficient method for the de-protection of trimethyl silyl alkynes using sodium Ascorbate and copper sulphate” UGC-CPE Sponsored one-day National conference on “Material Science and its application” on 04-May-2019, at BGS-College of Engineering, Uttarahalli, Bangalore.

      5. Presented a paper entitled on “Synthesis, characterization and biological studies of 1,2,4 triazole derivatives” in the National Symposium on “Recent Advantages at the Interface between Chemical & Biomedical Sciences” held at Indian Academy Degree College, Bangalore on 29th July 2019. (Secured 1st prize for best poster presentation)

      6. Presented a paper entitled on “Chemical synthesis, characterization of 1,2,4 triazole-3-thiol derivatives” in the International Conference on “Recent Advantages in Applied Sciences (ICRAAS-2019)” held at REVA University, Bengaluru on 17-18 October 2019.

      7. Presented a paper entitled on “Multistep synthesis, characterization and pharmacological properties of novel N-(4-fluorophenyl)-5-phenyl-[1,2,4] triazolo[1,5-a]pyridine-2-carboxamide” in the 1st International Conference on “Life, Chemical and Health Sciences (ICLCHS)” held at Ramaiah College of Arts, Science & Commerce in collaboration with Karnataka Science and Technology (KSTA), Bengaluru on 24th -26th October 2019. (Secured 2nd prize for best oral presentation)

      8.Presented a paper entitled on “Synthesis, antibacterial and antioxidant properties of ethyl 7-amino-3-benzoyl-2-methylindolizine-1- carboxylate derivative” in the 1st international conference on “Innovation and challenges in Science and Technology (ICICST)” held at Don Bosco Institute of Technology, Mysore Road, Bengaluru 560074, on 19th -23rd December -2019.

      9. Presented a paper entitled on “Microwave assisted synthesis, of 1, 2, 4 triazole derivatives and their biological evaluation.” held at The Indian Science Congress Association, Bengaluru on 07th January 2020.

      10. Presented a paper entitled on “A novel microwave assisted simple and shortest methodology for the synthesis of Oxazolidinone”, in the Two days National conference on “Recent Advances in Chemical Biology and Material Engineering (RACBME);” 30-31st January-2020, held at V.V Sangha’s Veerashaiva College, VSK University, Ballari, Karnataka.

  • • Online Course

      Successfully completed 3 days online courses on “BASIC PRINCIPLES OF SPECTROSCOPY” organized by Dept. of Chemistry AVS College of Arts & Science, Attur Main Road, Ramalingapuram, Salem-636 106.

  • • Research Projects Completed

      Served as Technical Research advisor for the following Research grants
      1) A major research project entitled “A novel 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivative inhibits tumor cell invasion and potentiates the apoptotic effect of TNFα by abrogating NF-κB activation cascade” Awarded by the DST-SERB with a grant amount of Rs 10, 00000 by SERB, No-SB/ FT/LS- 297/2012.

      2) A major research project entitled “Mo(CO)6as solid CO source in the synthesis of aryl/heteroaryl Weinreb amides under microwaveenhancedcondition.”Awarded by DST/Indo-South Africa with a grant amount of Rs 7, 00000 by AFRICA/P-12/2014.

      3) A major research project entitled“A new class of isobenzofuran-5-carboxamide derivatives: synthesis, studies on induction of apoptosis and inhibition cancer cell proliferation.” Awarded by UGC New Delhi Govt. of INDIA with a grant amount of 5,00000 by UGC-MRP, F.No. 41/224/2012.

  • • Awards

      1. Star award for prompt response for Environment Health & Safety incidence - (From Biocon Company- 2012)

      2) Developing Bio-transformation technology for Dorzolamide drug - (From Biocon Company-2015)

      3) Star award for valuable contribution towards new product development-(From Biocon Company -2015)

      4) Secured 1st prize for best poster presentation at national symposium. Indian Academy Degree College -2019)

      5) Secured 2nd prize for best oral presentation at International conference, Ramaiah College. Bangalore -2019)

  • • Seminar / Conference / Training attended

      1. UGC Sponsored National seminar at Manasagangotri, Dept. of Studies in Chemistry, Mysuru,2013.Presented an invite lecture on “DRUG DISCOVERY AND DEVELOPMENT”-Understanding the R&D Process” at JyotiNivas College Autonomous, Dept. of Studies in Chemistry, Bangalore,2019.

      2. UGC-CPE sponsored “Faculty Development Programme” in collaboration with Attitudeplus on 9th December-2018, at S. Nijalingappa College, KLE Society. Bangalore- 560010.

      3. Faculty Development Programme on “AN INNOVATIVE NEW GENERATION ENZYMATIC PCR” on 26th March- 2019 at Ramaiah College of Arts, Science &Commerce, Bangalore-560054.

      4.“New Methodology of Assessment & Accreditation by NAAC- Issues and Challenges” Organized by INTERNAL QUALITY ASSURANCE CELL (IQAC).on 11th April-2019 at Ramaiah College of Arts, Science &Commerce, Bangalore-560054.

      5. Faculty Development Programme on “Breakthrough Teaching: Moving from Curriculum Teaching to Student-centric Teaching on 18th, 19th and 20th June 2019” at Jyoti Nivas College (Autonomous), Koramangala, Bangalore-560095,

      6. Attended International Conference on Electronics, Physics &Chemistry-ICEPC 2017 in Jyoti Nivas College Autonomous Bengaluru-560095 on 16-17th February-2017.

      7. Successfully completed 3 days online courses on “BASIC PRINCIPLES OF SPECTROSCOPY” organized by Dept. of Chemistry AVS College of Arts & Science, Attur Main Road, Ramalingapuram, Salem-636 106.

      8. Attended webinar on “COVID-19 & its impact on Environment & Society: Bio & Physicochemical facts” Organized by Department of Chemistry, APS College of Arts & Science on 18th May 2020.

      9. Successfully completed the International Online Quiz on “COVID-19, PROTECTION AND PREVENTION” Organized by Mannar Thirumalai Naicker College (Autonomous) Affiliated to Madurai Kamaraj University, Centre for Competitive Examination on 23rd-May-2020.

      10. Attended online exam on “Research Reading Skill Exam” Organized by Pranveer Singh Institute of Technology (PSIT) Kanpur, Uttar Pradesh, on 23-06-2020. Reg No: FINIR0-CE000140.

      11. Participated in the Webinar on ‘Understanding Drug Development Process: Application To Discovery of COVID-19 Therapeutics’ Organized by Department of Chemistry. Indian Academy Degree College- Autonomous, Bangalore in Collaboration with ELSEVIER on 15th May 2020.

      12. Participated in the webinar on “The art of synthesizing organic compounds: A Researcher’s Perspective” Organized by Department of Chemistry, Sir Syed College, Taliparamba, Kannur, Kerala, INDIA -670142, on 04-06-2020.

      13. Participated in the National webinar on “IMPORTANCE OF ANTIVIRAL DRUGS IN 2020” (IAD-2020) Organized by Veerashaiva College Ballari, Dept. of Post Graduate studies in Chemistry on 12th-June-2020.

      14. Attended International webinar on “ADVANCEMENT IN CHEMICAL SCIENCES TOWARDS COVID-19” Organized by Rani Channamma University, Belagavi- 591156, Dept. of Chemistry on 12th-13th June-2020.

      15. Attended webinar on “Combat Corona – The New World Order” Organized by Jyoti Nivas College Autonomous, Bangalore-560095 on 16th-June-2020.

      16. Attended webinar on “Immunity and infection: Biochemical approaches to therapies” National Webinar Series (NWS)-2020, Organized by Dept. of Biochemistry and Society of Biological Chemists (India), Davangere Branch, Davangere University-577007, Karnataka, from 15th-21st June-2020.

      17. Participated in the International Conference “ICCS 2022” Organised by the Post Graduate centre, Dept. of Chemistry, Jyoti Nivas College Autonomous Bangalore on 23-25th June 2022.

  • • Seminar/Conference attended as Resource person

      UGC sponsored National seminar at Manasagangotri, Dept.of Studies in Chemistry, Mysuru, 2013. Presented an invite lecture on “DRUG DISCOVERY AND DEVELOPMENT”-Understanding the R&D Process” at Jyoti Nivas College Autonomous, Dept of Studies in Chemistry, Bangalore, 2019.

      UGC-CPE sponsored “Faculty Development Programme” in collaboration with Attitude plus on 9th December-2018, at S.Nijalingappa college, KLE Society. Bangalore- 560010.

      Faculty Development Programme on “AN INNOVATIVE NEW GENERATION ENZYMATIC PCR” on 26th March-2019 at Ramaiah College of Arts, Science &Commerce, Bangalore-560054.

      “New Methodology of Assessment & Accreditation by NAAC- Issues and Challenges” Organized by INTERNAL QUALITY ASSURANCE CELL (IQAC). on 11th April-2019 at Ramaiah College of Arts, Science &Commerce, Bangalore-560054.

      Faculty Development Programme on “Breakthrough Teaching: Moving from Curriculum Teaching to Student-centric Teaching on 18th, 19th and 20th June 2019” at Jyoti Nivas College (Autonomous) Koramangala, Bangalore-560007.

  • • Reviewer of international journals

      1. Chemical Data Collection (Elsevier).

  • • Membership of the Professional bodies

      1. A life time member of Indian Science Congress Association.

Jyoti Nivas College Autonomous, BANGALORE

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